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In contrast, ZDHHC9-mediated palmitoylation of cGAS at the 404/405 site is required for its dimerization and antiviral innate immunity signaling, and this process is inhibited by LYPLAL1 (69)

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Pivalic acid-containing antibiotics may also produce a secondary L-carnitine deficiency, as may certain chemotherapy agents

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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells