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The typical regimen involves: Loading dose for patients without neurological involvement : Hydroxocobalamin 1mg intramuscularly three times weekly for two weeks [13] [10] Loading dose for patients with neurological involvement : Hydroxocobalamin 1mg on alternate days until no further improvement, then Maintenance therapy : 1mg every two to three months (or every two months if neurological involvement) Lifelong maintenance therapy is necessary for irreversible causes such as pernicious anaemia or following gastric surgery

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A total of 12 articles [2 randomized controlled trials (RCTs) ( Effectiveness of Oral Vitamin B12 The data given in the studies all supported the use of oral vitamin B12 as a valid and effective way of treating vitamin B12 deficiency, including pernicious anemia

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