00:08:06 Sara Klockars: Thanks for having me
First, what are GLP-1 drugs and why do they matter for T1D
Genetic Factors That Influence Your Tirzepatide Response Timing The PlexusDx Precision Peptide Genetic Test analyzes GIPR (rs1800437) variants that relate to GLP-1 and related signaling pathways
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance
Protocol 1: Conservative sub-therapeutic approach Goal: Target inflammation with minimal metabolic impact Starting dose: 0.5 to 1.0 mg tirzepatide weekly Escalation: Increase by 0.25 to 0.5 mg every 4 to 6 weeks based on inflammatory marker response Target maintenance: The lowest dose that produces measurable CRP/IL-6 reduction Monitoring schedule: Baseline: hsCRP, IL-6, complete metabolic panel, body weight Week 4: hsCRP, symptom assessment Week 8: hsCRP, IL-6, body weight Every 8 weeks thereafter: full inflammatory panel Duration: Minimum 12 weeks to assess response, with ongoing reassessment Best for: Normal-weight individuals with elevated inflammatory markers, autoimmune patients who cannot afford weight loss This protocol uses the compounded tirzepatide dosage calculator approach since standard vials are not designed for sub-2.5 mg dosing
Before beginning any kind of treatment, it is important to take the necessary precautions