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In preliminary intervention studies, pharmacologic doses of betaine (1,500 to 6,000 mg/day) were found to reduce blood homocysteine concentrations in a small number of volunteers with normal-to-mildly elevated homocysteine concentrations (37-40)
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doi:10.1038/s41387-018-0017-1
It is generally represented by the formula: [R]NR 2 ] ~ , and is an extremely strong base, due to the extreme weakness of ammonia as Br0nsted acids
However, these ingredients are not tested as transdermal patches and further research is needed in this regard
Guillin, O
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