People have to keep taking semaglutide for the drug to keep working otherwise, theyll regain much of the weight, studies have shown
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In a phase II study, gastrointestinal side effects were most common during semaglutide dose escalation but weight loss persisted beyond these events and continued through the 52-week trial period [51]
In the withdrawal trial, participants switched to placebo regained about 14% over the following year. Tapering, at least 1.2 g/kg of protein, resistance training, and follow-up reduce the risk, but no post-stop protocol guarantees maintenance