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Literature review

To examine the occurrence of tumors in patients with low glutathione levels, the total glutathione and GSH levels in tumors and their matched normal tissues from the patients with colorectal cancer were measured

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Notably, in a recent chemical screen in the ferroptosis-sensitive HT-1080 N fibrosarcoma cells, seven out of eight PI3K/mTOR inhibitors suppressed the ferroptosis-inducing activity of erastin and sorafenib, but not the covalent GPX4 inhibitor, ML162 19