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Adipokines: adiponectin and leptin and their relationship with DPP-4 Adiponectin, another DPP-4 substrate hormone, is related to energy metabolism and is primarily secreted by brown adipose tissue and bone marrow adipose tissue [84]
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[1] [2] The medication works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to elevated blood glucose levels, suppresses glucagon release, and slows gastric emptying
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While the list of pathophysiologic defects continues to grow, the ominous octet provides a representation of 8 key defects found in T2DM ( Figure 1 )
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