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NMN is well tolerated in healthy participants who received 300, 600, or 900 mg per day for a total of 60 days 322,323 , with all NMN doses increasing blood NAD + levels, and no adverse events were observed

Longevity and maintenance The effects achieved may require continued treatment to maintain, and the discontinuation of treatment could result in a gradual return to normal skin tone

Week 3-4: visible improvement begins By week three, most users start noticing more obvious changes

Some users do exactly this

Window Months 3+ What People Often Report Cumulative skin and connective-tissue changes with cycle continuation

Paaske PB, Pedersen CB, Kjems G, Sam IL