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Thats because exendin-4 was close enough in its amino-acid sequence to provide the same effects as GLP-1, yet different enough that the same enzymes that broke down GLP-1 so quickly didnt have the same effect
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GLP-1 vs Traditional Weight Loss in Portland, Oregon: Which Method Works Best for Long-Term Results
Wegovy, Ozempic, Mounjaro, and Zepbound are FDA-approved brand-name products made by Novo Nordisk (semaglutide) and Eli Lilly (tirzepatide)
& Hukkanen, V
Eli Lillys surge has been fueled by unprecedented demand for GLP-1based obesity medicines such as Zepbound (tirzepatide) and anticipation around its oral obesity candidate, orforglipron, expected to gain regulatory approval early next year
