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Female BALB/c nude mice were applied for the xenograft experiments of human GBM cells (GSC derived from primary tumor resection samples), and male C57BL/6 N mice were employed for the intracranial transplantation assays of mouse GBM cells (mGSCs)
Around 70% of hepatocytes were lost early after transplantation due to neutrophil and macrophage/monocyte infiltration elicited by complement activation and cytokine release ( Complement system initializes innate immune system activation and shares a crosstalk with coagulation system
Physiol Rev 99, 2178
Several small clinical trials have nonetheless reported on the safety and tolerance of DSIP
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