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Glutathione modulates this pathway in multiple ways: it can shift melanin production toward the lighter pheomelanin, it interacts with intermediate molecules in the melanin pathway, and it helps maintain redox balance that affects enzyme activity inside melanosomes

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Therefore, it is the first head-to-head outcome trial of a gliptin versus an active comparator that is sufficiently powered to unveil potential differences in MACE occurrence between treatment groups [54]

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