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None have been tested in the rigorous, multi-phase clinical trial process that pharmaceutical GLP-1 medications undergo
It can lead to big changes
For example, a patient with a BMI of 28 and hypertension may be considered eligible even though they do not technically meet the obesity threshold
doi: 10.3988/jcn.2017.13.3.259 268
Current Opinion in Gastroenterology, 36(3), 264-271
The human body resists weight reduction due to complex homeostatic mechanisms
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