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La presencia de nutrientes especficos, como protenas y grasas, activa seales neurales y hormonales que promueven la liberacin de GLP-1

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However, Tirzepatide may be slightly more effective than Semaglutide

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Por otro lado, los inhibidores de la dipeptidil peptidasa-4, como la sitagliptina, que actan evitando la degradacin enzimtica del GLP-1 y el pptido inhibidor gstrico (GIP), han demostrado aumentar el riesgo de neuropata y de pancreatitis (Tang et al., 2025)