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Retatrutide works primarily through incretin and glucagon receptor activation

Tesamorelin/Ipamorelin is given as a single daily subcutaneous injection on a provider-determined schedule

In the SURMOUNT-5 head-to-head trial against semaglutide, tirzepatide at maximum dose produced 20.2% weight loss compared to semaglutide at 13.7%

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Discuss cycling strategies with your prescribing clinician based on your IGF-1 trends and symptom response