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Briefly, TRPs are Ca 2+ -permeable channels known for their role in temperature sensation, but interestingly, have also been shown to play a role in the release of pro-inflammatory cytokines from microglia in mice exposed to immunogenic agents [i.e., lipopolysaccharide (LPS)] (Zhang Y

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STAT1/3 signaling suppresses axon degeneration and neuronal cell death through [PMID: 37187216] Laboratory literature summary: STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD(+)-biosynthetic and consuming enzymes

This diminishes cystine absorption and glutathione production, thereby accelerating the formation of lipid-reactive oxygen species ( This review offers a comprehensive and critical examination of recent data on the bidirectional relationships and molecular pathways linking macrophage biology to ferroptotic cell death processes in various clinical settings