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doi:10.1038/nature04056
Whether reducing NNMT activity would directly reverse these changes in humans remains an open research question
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If human trials with the compound show safety and efficacy, NNMT inhibitors like 5-amino-1MQ could serve to prevent and/or slow age-related muscle deterioration in humans, a tantalizing prospect
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The problem with prolonged caloric deficit is that metabolic adaptation your body downregulates energy expenditure over time to resist the deficit
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