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This is because, in comparison to GLP-1, semaglutide has two amino acid substitutions, which makes it less vulnerable to degradation by the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) [97] and gives it the distinct advantage of increased albumin affinity [96]

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doi: 10.1016/j.peptides.2020.170389 140 HuangKPRonveauxCCDe LartigueGGearyNAsarianLRaybouldHE

The transcriptional and signalling networks of pluripotency

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A distinctive effect from the phase 3 data is dysesthesia, a skin-sensation symptom described as tingling or sensitivity, more common at higher doses