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Beyond contributing to the conceptual knowledge of appetite and energy balance regulation in humans [12], we also made potentially clinically important discoveries, such as why dietary protein provides greater immediate satiety than the other macronutrients and why milk is more satiating than sugar-sweetened soft drinks (both dietary exposures increase GLP-1 relative to their comparators) [13]

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Remarkably, this method demonstrated a reduction in heat sensitivity that was comparable to, or even exceeded, that observed with intraperitoneal administration (Fig

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