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For those with type 2 diabetes, particularly when combined with other diabetes medications, GLP-1's may increase the risk of hypoglycemia (low blood sugar)
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This creates an unusual situation: ARA-290 has Phase 2 clinical data of reasonable quality, regulatory designations that recognized its therapeutic promise, and a well-characterized mechanism with a solid scientific foundation but no ongoing clinical development program or path to approval
doi: 10.1016/j.molliq.2020.114501 129 SantraSDhuruaSJanaM
