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407 In contrast, the ATTRACTION-4 trial, which investigated nivolumab plus SOX or CAPOX in gastric/EGJ cancer, met its PFS endpoint (HR = 0.68, P = 0.0007) but did not demonstrate a statistically significant improvement in OS (HR = 0.90, P = 0.26), potentially influenced by high rates of subsequent therapy, including ICIs, in the control arm

The cluster analyses underscore the challenges in finding overlaps between real-world and RCT data, emphasizing the necessity for advanced methods to identify matching external controls

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