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So one ongoing question in the field is to identify the phenotypes, the subgroups of people who may be more responsive to these medications. Other challenges include patient adherence to treatment, which 20 percent of physicians cited as a challenge, and side effect management, which 18 percent of physicians cited as a challenge

However, assessment of long-term, hard clinical kidney endpoints has been limited by the three- to fivefold higher risk of hyperkalaemia with spironolactone use [66]

Singh U, Devaraj S, Jialal I

And then they're part of this collaborative team and we love them

Dourado, D

These gastrointestinal effects may increase blood viscosity and increase the risk of clot formation