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A post hoc analysis of data from SURPASS-4 showed that tirzepatide is effective in reducing the risk of worsening renal function compared with insulin glargine

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They physically block the receptor from interacting with G proteins, which terminates signaling

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Contrary to expectations, glycaemic control was also improved after chronic treatment with the GLP-1R/GcgR co-agonist, which implies that GLP-1 activity protected against glucagon-induced hyperglycaemia [17]

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