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while tirzepatide is not a classic CYP substrate, people taking multiple drugs (e.g., antidepressants, oral contraceptives) may face confounding interactions and potentially fluctuating glucose control

Furthermore, the rather long distance of 5.8 between the SG2 atom of GSH and the OG atom of Ser20 residue suggests that the H-site bound GSH reacts with G-site bound GSH rather than the active site cysteine residue

doi: 10.3389/fendo.2022.810242

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Immediately after the alcohol or water administration, rats were placed in the chambers and after a 20-minute delay (allowing for blood and brain alcohol levels to rise and assessment to occur in the ascending limb of the alcohol curve: Quertemont et al

These effects have not been linked to retatrutide in current trials