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The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons
The evidence suggests that the problem is caused by gut bacteria but perhaps not necessarily those in the small intestine
(2024a)
Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )
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MDPI papers suggest this is often a mast cell response to the peptide concentration
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