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12 Based on current cardiovascular outcome data such as that provided in SUSTAIN-6, the American Diabetes Association (ADA) now recommends GLP-1 receptor agonists with proven cardiovascular benefit as a preferred option for second-line add-on therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) following metformin and lifestyle-change intensification

These risks may, however, be elevated in individuals with long-standing T2D even in the absence of GLP-1RA treatment

10.1038/s41467-025-58964-3 109 Morn LuengoT.MayerM

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2.2 Anti-tumor effects of Gln metabolism Gln, a crucial nutrient in the TME, supports the growth of tumor cells

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