One peptide with reduced internalization and improved insulinotropism, exendin-phe1, and one with opposing characteristics, exendin-asp3, were selected for further studies (Fig
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They continue drawing the same number of units as before without realizing the concentration has changed
The US investigation is still ongoing, however, and has been broadened to include Lillys dual GLP-1/GIP agonist tirzepatide, approved as Mounjaro for obesity and Zepbound for obesity