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Description

Common impurities include: -Deamidation (+0.984 Da) -Oxidation (+16 Da) -Des-acylated forms (266 Da) -Truncated peptides -Isomerization (Asp/isoAsp) These must be identified and quantified during impurity profiling

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Significantly decreased insulin and insulin receptor expression was observed in postmortem AD brain tissue, and changes in downstream insulin signaling molecules, including decreased levels of IRS-1/2, PI3K, p-Akt (51, 54)

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Altering dose timing by a day or two, however, may be a viable option

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