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Histamine binds to receptors on small blood vessels, making vessel walls more permeable (which allows fluid to leak and form the raised wheal) and dilating the vessels (which creates the surrounding redness)
1 x Ampoule of Vitamin C Injection IP 500 mg/5ml
The body may get used to the constant stimulation, so the same dose may stop working as well
Notably, when the GSH level decreases, impaired negative-feedback inhibition leads to the accumulation of -glutamylcysteine, which is converted to 5-oxoproline via the -glutamylcyclo-transferase pathway
Cancers (Basel) 15 (4), 1116
Biol Psychiatry 30 : 10591062
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