Elastin, on the other hand, is synthesized during wound healing and, although it accounts for only a small fraction of ECM (0.6%7.9%), is essential for reducing scar contraction, promoting skin regeneration and giving the wound area the necessary flexibility
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Exceptionally low or high IGF-1 levels are associated with an increased risk of dementia and stroke, and high levels are linked to an increased risk of Parkinsons disease 40
When activated the HGF/Met system has been shown to stimulate mitogenesis, motogenesis, morphogenesis and protect against tissue insults in several cellular targets including epithelial, endothelial, and neurons