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Bibcode:2010PNAS..107.6526O

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

When you combine them, you may get a synergistic effect

Fumarate is also a known agonist of nuclear factor erythroid 2 p45-related factor 2 ( Nrf2 ) [48] which has been shown to improve synaptic plasticity, learning, and memory in the hippocampus [49, 50]

Safety information: Pregnant, nursing women or individual taking any medications, consult the doctor before use

Availability may be scarce, as the categorical status of CJC-1295 and ipamorelin is in limbo