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The patient was positioned in a normal seated position and placed her wrist inside the InReach bore
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The major conformational clusters from each of the MD simulations were obtained with the graph-based program BitQt 61
Proper Dosage: Ensure dosage recommendations come from medical professionals, avoiding self-medication or unverified sources
On the day of the assay, serial dilutions (7-fold dilutions, 7 concentrations per compound and one well containing only assay buffer) of test compounds were performed in duplicate in assay buffer to appropriate concentrations in 96-well plates (Greiner, U-shape #GR-650201) using a Biomek i7 liquid handler
