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Previous studies identified that mutation of Y211 to phenylalanine resulted in reduced carnitine transport whereas the transport of the cationic probe compound tetraethylammonium was unaffected 16 , indicating that Y211, through its hydroxyl moiety, plays a role in recognising the carboxyl of carnitine

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In preclinical models this combination showed an additive effect

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More recently, however, an animal study based on a tandem stenosis mouse model showed the ability of SGLT2is to stabilize atherosclerotic plaques, with increased fibrosis, augmented collagen accumulation, and significant upregulation of the expression of vasculoprotective NADPH oxidase 4 [18]