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McCarty said

In studies using the shrew, a well-established animal model for nausea and vomiting, co-administration of GIPRA almost completely abolished GLP-1RA-induced nausea while preserving its anorexigenic effect [32]

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Protective Effect of Metformin against Ovariectomy Induced Depressive- and Anxiety-like Behaviours in Rats: Role of Oxidative Stress