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The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia
The cardiovascular benefits begin immediately rather than after damage has accumulated
Vernieri, C
Lancet 372 , 19061913 (2008)
Multi-agonist therapies combining GLP-1 with GIP or glucagon may amplify these benefits by improving fat metabolism and reducing cardiovascular risk even further
Abbasinejad, MD , evaluates each patients medical history, current weight, previous weight loss efforts, medications, lifestyle, and overall health goals before determining whether Contrave may be appropriate
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