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Typical DFT results for GHK-Cu show strong overlap between copper d-orbitals and nitrogen lone pairs, supporting a square-planar geometry
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What they omit: the same property that reduces IGFBP binding also means less buffering of free IGF-1 at all tissues, including those where IGF-1 receptor signaling is not wanted
Selected Research References Gwyer D, Wragg NM, Wilson SL
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