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Bactrim contains sulfonamide (a molecule composed of sulfur, oxygen, nitrogen, and hydrogen), and an allergic reaction to this medication is not due to the chemical makeup of sulfonamide, but rather the mechanism of action of the drug
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Front Cell Dev Biology 8:51 Akhtar M, Guo S, Guo Y-F, Zahoor A, Shaukat A, Chen Y, Umar T, Deng G, Guo M (2020) Upregulated-gene expression of pro-inflammatory cytokines (TNF-, IL-1 and IL-6) via TLRs following NF-B and MAPKs in bovine mastitis
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Br J Pharmacol 2016;173:1820-34.ArticlePubMedPMC 48
Together, these effects may help explain trends observed in recent studies examining GLP-1 therapies and CKD progression
