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While your body produces it naturally, levels decline with age, stress, and environmental toxin exposure

PMC6271067 Hsieh, M.J., et al

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Additionally, the degree of endothelial senescence positively correlated with the level of expression of two surface molecules linked to vascular disease, the intracellular adhesion molecule-1 and type 1 plasminogen activation inhibitor (Xu et al, 2000)