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Discovered in 2015, MOTS-c functions as a signaling molecule that helps the body respond to metabolic stress by improving glucose uptake, enhancing insulin sensitivity, and promoting fat metabolism

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It is involved in both chronic and acute inflammatory processes

doi: 10.1097/MIB.0000000000000750 80 BisanzJEUpadhyayVTurnbaughJALyKTurnbaughPJ

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Altered B12 handling and reduced clearance in kidney disease, and both cellular release and reduced clearance in liver disease, can raise B12, so supportive renal or hepatic findings make those causes plausible