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Macrogol is an osmotic laxative that draws water into the bowel to soften stools and is recommended by NICE as first-line treatment for chronic constipation in adults Constipation affects 1-10% of Ozempic users and over 10% of Wegovy users, caused by semaglutide's effect on gastrointestinal motility Bulk-forming laxatives like ispaghula husk may suit mild constipation but require adequate fluid intake to prevent obstruction Stimulant laxatives such as senna or bisacodyl provide short-term relief for severe constipation and should be used under medical supervision No specific laxative interactions with Ozempic are documented, but patients should inform healthcare providers of all medications taken Persistent or severe constipation, abdominal pain, vomiting, or inability to pass stool requires urgent medical assessment Not sure where to start

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Further, a clinical trial of over 3,000 people living with type 2 diabetes and chronic kidney disease found that semaglutide led to improvement for kidney, cardiovascular, and survival outcomes including a 24% reduced risk of kidney disease events and18% lower risk of major cardiovascular events compared to placebo

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When levels are low, it can lead to fatigue, brain fog, low mood, and general weakness

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