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Mycologia 92(6):10331042 Tan SX, Greetham D, Raeth S, Grant CM, Dawes IW, Perrone GG (2010) The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae

Key findings: Pharmacokinetics were dose proportional Steady-state exposures were maintained with once-weekly dosing Body weight reduction was dose-dependent: up to -8.96 kg in the highest dose group vs placebo at 12 weeks HbA1c reductions of -0.4% to -1.2% across dose groups Safety profile consistent with other incretin drugs (GI adverse events most common) Drug Interactions and Kidney Function: What Has Been Studied oral drug taken alongside it

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