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Avoid freezing, as freeze-thaw cycles degrade the peptide
In the SURPASS-2 trial, which directly compared tirzepatide to semaglutide 1 mg for type 2 diabetes, nausea rates were 17-22% for tirzepatide across all three dose levels (5 mg, 10 mg, and 15 mg) versus 18% for semaglutide 1 mg
High drug levels can lead to more side effects, like severe heart rhythm problems with erythromycin and rilpivirine, or dangerously low blood pressure with maraviroc
One recent study found that these issues affected 90% of study participants in the first eight weeks of treatment
Samimi and colleagues found that LC supplementation (250 mg per day orally for 12 weeks) lead to significant reduction in body weight, BMI, waist and hip circumference respectively as well as improved glycemic control in women with PCOS (mean age 24.8 5.5 years) [12]