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Accessed May 2023 at 3

Presented for research literature review only Anderson JV et al

For this reason, a relatively high starting concentration was needed to reliably induce the phenotype being studied

While formal drug interaction studies are limited, AOD-9604 can often be safely combined with other therapies under proper medical supervision

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These observations support a paradigm, in which Ca 2+ /CaSR signaling counteracts PTHrP/PTH1R signaling by suppressing PTH1R expression, independently, of IGF1/IGF1R signaling and by inhibiting PTHrP expression via the IGF1/IGF1R pathway to support normal progression of chondrocyte differentiation and growth plate development (Figure 1)