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The primary endpoints were changes in patient-reported quality of life using the KCCQ clinical summary score and changes in body weight

These alternate routes generally deliver a fraction of the active dose of injection due to peptide degradation in the digestive tract, which is why injection remains the clinical standard

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doi: 10.1038/35010121 160 BrdickaTPavlistovaDLeoABruynsEKorinekVAngelisovaPet al

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