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Furthermore, phenformin could also display synergism with other anti-cancer molecules (i.e., immune-therapeutics, chemotherapeutic)
GO term enrichment was then assessed using the enrichGO function from the ClusterProfiler 30 R package, with the parameter universe set to include all genes detected in the bulk RNA-seq data, minGSSize set to 10, maxGSSize set to 500 and pAdjustMethod set to BH
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48 JAK/STAT signaling pathway The janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway is involved in cell proliferation, differentiation, apoptosis, and inflammation response
There are no large controlled human trials establishing combined efficacy or safety, and the pairing remains a subject of ongoing preclinical interest rather than clinical fact
