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Adapted from: de Bray A, et al

10.1056/NEJMoa1411892 34

For context, semaglutide and tirzepatide do not produce dysesthesia at clinically significant rates, though a recent paper in PMC examined allodynia and dysesthesia reports across GLP-1 medications more broadly

297 , E1023E1029 (2009)

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This endothelial damage exposes underlying collagen, which triggers platelet hyperactivation and the persistent formation of these microclots