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The most commonly cited starting protocol in the medical literature and clinical practice involves 250 micrograms administered once daily for acute injury, stepping up to 500 micrograms daily if response is insufficient after one to two weeks

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If irritation occurs, discontinue use immediately

doi: 10.1016/j.bbabio.2018.04.002 183 BudaAQualtroughDJepsonMAMartinesDParaskevaCPignatelliM

Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial

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