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Importantly, NC-6300 normalizes the TME by increasing blood vessel maturity and reducing fibrosis, leading to increased intratumor density and proliferation of T cells when combined with checkpoint inhibition

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When GLP-1, GLP-2, or VIP were added to these neuronmast-cell co-cultures, researchers observed complete reversal of neuronal death, with all three peptides enhancing neuronal survival in a concentration-dependent manner