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Ansamycin derivatives such as 17-AAG (tanespimycin) and 17-DMAG (alvespimycin) reduce tau and -synuclein oligomerization in AD and PD models by promoting their degradation via the ubiquitinproteasome system
These days, this motley crew of experimental drugs is experiencing a renaissance online, but are these drugs legal or safe
Furthermore, the degree of reduction in glutathione seems to parallel the severity of the PD
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Many patients can resume usual therapy after surgery once they are tolerating oral intake and the prescribing clinicians plan is clear
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