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Solar ultraviolet radiation at the earths surface
Total cellular extracts (200 g of protein) were incubated with an anti-IKK- antibody (1 g/mL) in IP buffer overnight at 4 C on a rocker
Condensed Matter : an Institute of Physics Journal, 29 (20), Article 203002
FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
Anisimov VN, Khavinsov VKh, Alimova IN, Provintsiali M, Manchini R, Francheski K
Prebiotic supplementation has shown sex-specific improvement in PTSD symptoms, linked to enhanced SCFA production and gut microbiota modulation in males (Voigt et al., 2025)
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