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2.2.2 Heat stress adaptation of the spermatogenic microenvironment The spermatogenic microenvironment refers to the local cellular and structural niche formed by Sertoli cells, Leydig cells, germ cells, and the bloodtestis barrier, which provides the essential conditions for spermatogenesis, including nutrient support, hormonal signaling, and immune privilege, thereby supporting normal sperm development (Frana et al., 2016)
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Quercetin, GSH, vitamin C, vitamin B9, carotenoids, carnitines, polydatin, and taurine have also been reported to protect the testis from damage and improve semen quality, but their roles in ferroptosis have not been elucidated [127,128,129,130]
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